About Nervana PEMF
What is PEMF?
Pulsed Electromagnetic Field (PEMF) therapy is a non-invasive treatment that uses electromagnetic waves to promote healing and improve overall health. It works by stimulating cellular production of nitric oxide which leads to vasodilation ( a widening of the blood vessels), thereby enhancing blood and lymphatic circulation.
PEMF technology in the past 50 years has been refined, tested and clinically-proven to accelerate natural healing. The results: safe, natural, effective methods for repairing soft tissue, reducing swelling and relieving pain.
About Nervana PEMF
How PEMF Works
PEMF devices operating at 27.12 MHz generate a pulsed electromagnetic field that penetrates tissue non-invasively. This oscillating field induces microcurrents within biological tissues that stimulate cellular and subcellular processes.
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Non-thermal, low-energy fields: Unlike continuous shortwave diathermy, PEMF delivers brief pulses that do not heat or damage tissue.
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Cellular biophysics: Pulsed fields interact with membrane potential and ion channels (e.g., Ca²⁺ flux), which can influence downstream signaling (e.g., nitric-oxide pathways), microcirculatory tone, and edema dynamics.
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Neuro-modulatory effects: Published work suggests PEMF can dampen peripheral nociceptive input and reduce central sensitization risk in chronic pain states.
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Tissue effects: Studies report reduced swelling and stiffness, improved comfort and function, and faster return to activity when used adjunctively with rehab.
How PEMF Works
Cellular Bioenergetics
The pulsed 27.12 MHz field modulates mitochondrial oxidative phosphorylation, leading to:
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↑ ATP generation
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↓ Reactive oxygen species (ROS)
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↑ Mitochondrial membrane potential
This creates an energy-rich environment that supports cell proliferation, collagen synthesis, and tissue remodeling.
How PEMF Works
Ionic and Membrane Effects
The induced currents influence ion channel kinetics, particularly for:
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Calcium (Ca²⁺)
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Sodium (Na⁺)
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Potassium (K⁺)
How PEMF Works
Nitric Oxide and Microcirculation
PEMF exposure increases endothelial nitric oxide synthase (eNOS) activity, causing:
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Vasodilation
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Improved microvascular perfusion
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Enhanced oxygenation and nutrient delivery
This improved hemodynamics reduces ischemic pain and accelerates inflammatory resolution.
How PEMF Works
Inflammatory Modulation
At 27.12 MHz, PEMF has been shown to:
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Down-regulate pro-inflammatory cytokines (TNF-α, IL-1β, IL-6)
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Up-regulate anti-inflammatory cytokines (IL-10)
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Stabilize cell membranes and mast cells, reducing histamine release
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Promote macrophage M2 polarization (pro-healing phenotype)
These combined effects translate into pain reduction, edema control, and accelerated healing.
How PEMF Works
Pain Modulation
Analgesic effects are achieved via:
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Hyperpolarization of neuronal membranes (reducing nociceptive firing)
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Increased β-endorphin release
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Reduced C-fiber transmission
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Improved synaptic neurotransmitter regulation
Clinically, this leads to decreased perception of pain without nerve desensitization or systemic pharmacologic effects.
